Hierarchical Nano-Bio Materials - Dr. Munish Chanana

The road between the Nanoworld and the Bioworld is a two-way road. Going one or the other way, one can address the demands and problems of various fundamental and applied scientific fields, such as biomedicine, material- and environmental sciences.

The incorporation of functional nanoparticles (e.g. magnetic, plasmonic or fluorescent NPs) in biomaterials yields nano-bio hybrid materials that exhibit novel properties that go beyond the natural ones. For example, the incorporation/assembly of the superparamagnetic magnetite nanoparticles in anisotropic and hierarchical structure of wood materials, yields a magnetic wood material, with a magnetic anisotropy dictated by the wood structure. By the incorporation of inflammable and non-hazardous minerals such as calcium carbonate in the wood structure, fire-retarding wood materials are obtained.

On the other hand, the decoration of biomolecules and biopolymers onto nanoparticles, yields biocompatible and colloidally stable nanosystems with a defined bio-interface. Polypeptides and proteins enhance the physico-chemical and colloidal properties of nanoparticles (e.g. plasmonic metal nanospheres and nanorods), making them highly suitable for biomedical applications. Such systems can be further assemble to 2D and 3D super-structures, providing a versatile platform for plasmonic sensors and SERS-enhancing structures.

Using the diversity offered by both biomaterials (incl. biomolecules, biopolymers) and nanomaterials (organic and inorganic) and their inter-combinations, we aim to create a stronger bridge between the two worlds.

The research activities of the group of Hierarchical Nano-Bio-Materials are focused on both pathways, including:

Synthesis of colloidally stable organic and inorganic nanoparticles

Enlarged view: SYNTHESIS OF COLLOIDALLY STABLE ORGANIC AND INORGANIC NANOPARTICLES_ CHANANA MUNISH
An example of gold nanoparticles of different sizes

Protein- and Enzyme-coated Nanoparticles

Enlarged view: Protein and enzyme coated nanoparticles; Munish Chanana
1.Dewald, I.; Isakin, O.; Schubert, J.; Kraus, T. and Chanana, M.*, Protein Identity and Environmental Parameters Determine the Final Physico-Chemical Properties of Protein Coated Metal Nanoparticles, J. Phys. Chem. C 2015, 119 (45), pp 25482–25492 2.Tebbe, M.; Kuttner, C.; Männel, M.; Fery, A.; Chanana, M.*, Colloidally Stable and Surfactant-Free Protein-Coated Gold Nanorods in Biological Media. ACS Applied Materials & Interfaces 2015, 10.1021/acsami.5b00335 3.Chanana, M.*; Correa-Duarte, M. A.; Liz-Marzán, L. M., Insulin-Coated Gold Nanoparticles: A Plasmonic Device for Studying Metal–Protein Interactions. Small 2011, 7 (18), 2650-2660 4.Chanana, M.*; Rivera_Gil, P.; Correa-Duarte, M. A.; Liz-Marzán, L. M.; Parak, W. J., Physicochemical Properties of Protein-Coated Gold Nanoparticles in Biological Fluids and Cells before and after Proteolytic Digestion. Angew. Chem. Int. Ed. 2013, 52 (15), 4179-4183

3D Assembly of Plasmonic Nanoparticles to Core-Satellite Structures

Enlarged view: 3D assembly of plasmonic nanoparticles to core satellite structures; Munish Chanana
Scalable 3D assembly of plasmonic metal nanoparticles. Here is an example of gold/gold core/satellite nanoclusters (in collaboration with IPFDD and University of Bayreuth) Höller, R.P.M;  Dulle, M.; Thomä, S.; Mayer, M.; Steiner, A.M.;  Förster, S.; Fery, A.;  Kuttner, C.; and Munish Chanana*, Protein-Assisted Assembly of Modular 3D Plasmonic Raspberry-like Core/Satellite Nanoclusters: Correlation of Structure and Optical Properties. ACS Nano 2016, DOI: 10.1021/acsnano.5b07533

Former projects

2D Assembly/Synthesis of inorganic (metal) nanoparticles in the hierarchical structure of wood materials

PhD student: Vivian Merk

2D assembly synthesis of inorganic (metal) nanoparticles in the hierarchical structure of wood materials; Vivian Merk
An example of 2D assembly of iron oxide nanoparticles on the inner cell wall of cell lumens of wood yielding anisotropic yielding wood

Mineralization of wood materials at different scales of hierarchy (from nanopores to mesopores)

PhD student: Vivian Merk

Mineralization of wood materials at different scales of hierarchy; Vivian Merk
Control over mineral (CaCO3) distribution using non-ionic (left) or ionic (right) carbonate source...read more Picture on the left: Merk, V.; Chanana, M.*; Keplinger, T.; Gaan, S.; Burgert, I., Hybrid wood materials with improved fire retardance by bio-inspired mineralisation on the nano- and submicron level. Green Chemistry 2015, 10.1039/C4GC01862A Picture on the right: Merk, V.; Chanana, M.*; Gaan, S.; Burgert, I., Mineralization of wood by calcium carbonate insertion for improved flame retardancy. Holzforschung 2016, DOI 10.1515/hf-2015-0228

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